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Mechanism of Decompensation Evaluation - Aortic Stenosis

NCT03332745 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 90

Last updated 2024-05-13

No results posted yet for this study

Summary

Aortic stenosis is the most common heart valve disease requiring intervention in high income countries. It is characterised by progressive valvular thickening, and restriction as well is hypertrophy and fibrosis of the left ventricle in response to pressure overload. The pathological processes in the left ventricle that ultimately result in heart failure and death are incompletely understood. Further elucidation of these processes and how they correlate with novel blood biomarkers may help us design new treatments and optimise the timing of surgical intervention.

In brief, recruited patients with severe aortic stenosis and scheduled to undergo valve replacement surgery will be invited for some simple tests (blood sampling, ECG, echocardiogram). A septal myocardial biopsy will be taken at the time of surgery and the disease valve retained. These will be examined histologically and pathological changes compared with results obtained from ECG, echocardiogram and blood tests.

Conditions

  • Aortic Stenosis
  • Myocardial Fibrosis
  • Left Ventricular Hypertrophy

Sponsors & Collaborators

  • University of Edinburgh

    lead OTHER

Principal Investigators

  • Russell J Everett, MBBS · University of Edinburgh

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-09-03
Primary Completion
2021-08-12
Completion
2023-07-31

Countries

  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03332745 on ClinicalTrials.gov