Craniofacial Microsomia: Accelerating Understanding of the Significance and Etiology

Summary

The CAUSE study is a multicenter study, with domestic (n=4) and international (n=6) study sites. Children and young adults (ages 0-18) who have microtia and/or craniofacial microsomia and their parents are invited to participate. Children and parents are asked to provide a DNA sample (blood or saliva) and are asked to upload a few photos of their face. Parents are asked a short interview. Participants are able to participate from home or at one of four domestic sites.

Conditions

• Microtia
• Microtia-Anotia
• Craniofacial Microsomia
• Goldenhar Syndrome
• OAVS
• OAV Syndrome
• Hemifacial Microsomia

Sponsors & Collaborators

• Children's Hospital Los Angeles

  collaborator OTHER

• Children's Hospital of Philadelphia

  collaborator OTHER

• University of North Carolina, Chapel Hill

  collaborator OTHER

• Pontificia Universidad Javeriana

  collaborator OTHER

• Universidad Icesi

  collaborator OTHER

• Hospital Nacional Edgardo Rebagliati Martins

  collaborator OTHER

• Instituto de Investigación Hospital Universitario La Paz

  collaborator OTHER

• Clinica Comfamiliar Risaralda

  collaborator UNKNOWN

• Seattle Children's Hospital

  lead OTHER

Principal Investigators

• Carrie Heike, MD, MS · Seattle Children's Hospital

Eligibility

Min Age

0 Years

Max Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2018-02-23

Primary Completion

2021-11-30

Completion

2023-08-30

Countries

• United States
• Colombia
• Peru
• Spain

Study Locations