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Impact of Zinc and Vitamin D3 Supplementation on the Survival of Aged Patients Infected With COVID-19

NCT04351490 · Status: WITHDRAWN · Phase: NA · Type: INTERVENTIONAL

Last updated 2021-03-11

No results posted yet for this study

Summary

Mortality from Covid-19 increases with age, reaching 14.8% from the age of 80. The severity of the infection is linked to the acute respiratory distress syndrome (ARDS) which requires intensive care. ARDS is the consequence of the reactional inflammatory storm that damages the lungs.

Aged subjects are particularly prone to zinc and vitamin D deficiency. These two micronutrients are able to modulate the immune response by reducing the inflammatory storm.

The hypothesis is that supplementation with zinc and vitamin D would reduce the inflammatory reaction which worsens ARDS and leads to the death of subjects infected with Covid-19.

Conditions

  • SARS-CoV 2

Interventions

DIETARY_SUPPLEMENT

Zinc gluconate

Zinc gluconate capsule 15 mg x 2 per day during 2 months

DIETARY_SUPPLEMENT

25-OH cholecalciferol

25-OH cholecalciferol drinkable solution 10 drops (2000 IU) per day during 2 months

Sponsors & Collaborators

  • University Hospital, Lille

    lead OTHER

Principal Investigators

  • David SEGUY, MD,PhD · University Hospital, Lille

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
60 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-04-30
Primary Completion
2020-07-31
Completion
2020-07-31

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04351490 on ClinicalTrials.gov