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LRRK2 Activity and Markers of Parkinson's Disease in G2385R Carriers

NCT04349865 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 211

Last updated 2021-02-09

No results posted yet for this study

Summary

The goals of this study are

1. To compare the functional effects of the LRRK2 G2385R variant among carriers with and without Parkinson's disease (PD) and non-carriers with and without PD
2. To investigate the relationship between functional effects of the LRRK2 G2385R variant and PD associated phenotype
3. To investigate the biomarkers associated with PD conversion in the LRRK2 G2385R variant carriers
4. To compare the immune-related differences between PD patients/unaffected individuals with and without the LRRK2 G2385R mutation, and to investigate the effects of immune dysfunction on the clinical expression of PD

Conditions

  • Parkinson Disease

Sponsors & Collaborators

  • Michael J. Fox Foundation for Parkinson's Research

    collaborator OTHER

  • Xuanwu Hospital, Beijing

    lead OTHER

Principal Investigators

  • Piu Chan, MD, PhD · Xuanwu Hospital of Capital Medical University

Eligibility

Min Age
55 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2018-05-22
Primary Completion
2020-12-25
Completion
2020-12-25

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04349865 on ClinicalTrials.gov