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Vitamin D and Health Outcomes in Preterm Born Population

NCT04342078 · Status: ACTIVE_NOT_RECRUITING · Type: OBSERVATIONAL · Enrollment: 87

Last updated 2023-11-29

No results posted yet for this study

Summary

Improved survival of very preterm newborn population during the last decades has challenged us neonatologists to study and improve nutritional practices including vitamin D (VitD) supplementation. However, long term outcome in this aspect has not been researched in well documented preterm populations. As VitD has receptors in almost all human cells it modulates growth of many organs. Therefore I start to assess VitD supplementation practices and later health outcome (bones, teeth, muscles, heart, lungs) in two preterm population cohorts cared in Oulu University Hospital at the age of 5 years and 24 years (born 2014-2017 and 1994-1997).

Conditions

  • Vitamin D3 Deficiency
  • Prematurity
  • Lung Diseases
  • Heart Rate Variability
  • Stress Physiology
  • Bone Diseases, Metabolic

Interventions

DIETARY_SUPPLEMENT

Vitamin D

To investigate the effect of one year vitamin D supplementation in preterm born adults (4000 IU = 100 micrograms a day if serum concentration is \< 30 nmol/l, 2000 IU = 50 micrograms a day if 30-50 nmol/l and 1000 IU = 25 micrograms a day if \> 50-80 nmol/l, and no additional supplement if \> 80 nmol/l) on health outcomes (bones, teeth, muscles, heart, lungs) . The target level of vitamin D concentration by every 4 months interval is 80 - 120 nmol/l .(Preterm Adult group)

Sponsors & Collaborators

  • University of Oulu

    lead OTHER

Principal Investigators

  • Marita Valkama, Docent · MRC, University of OUlu

  • Marja Ojaniemi, Docent · MRC, University of Oulu

Eligibility

Min Age
5 Years
Max Age
25 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2018-09-01
Primary Completion
2023-12-31
Completion
2023-12-31

Countries

  • Finland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04342078 on ClinicalTrials.gov