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Acute Effects of GLP-1 on Renal Hemodynamics

NCT04337268 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 10

Last updated 2020-04-07

No results posted yet for this study

Summary

This study investigates the hypothesis, that GLP-1's suppression of ANG II and natriuretic action increase medullary perfusion and decrease oxygen consumption, leading to higher tissue oxygenation.

Conditions

  • The GLP-1-mediated Gut-kidney Axis

Interventions

DRUG

Glucagon-Like Peptide 1

Intravenous infusion (1.5 pmol/kg/min) for 60 min.

DRUG

saline 0.9%

Intravenous infusion for 60 min.

Sponsors & Collaborators

  • Department of Cardiovascular and Renal Research, University of Southern Denmark

    collaborator UNKNOWN

  • Rigshospitalet, Denmark

    lead OTHER

Principal Investigators

  • Ali Asmar, MD, PhD · Rigshospitalet, Denmark

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Model
CROSSOVER

Eligibility

Min Age
20 Years
Max Age
60 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2019-04-01
Primary Completion
2020-03-01
Completion
2020-03-01

Countries

  • Denmark

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04337268 on ClinicalTrials.gov