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Comparison of Pulsed-field Gel Electrophoresis and Whole Genome Sequencing to Determine Transmission Rate of ESBL-producing E.Coli

NCT04323553 · Status: TERMINATED · Type: OBSERVATIONAL · Enrollment: 43

Last updated 2025-01-15

No results posted yet for this study

Summary

The aim of this quality control study is to compare two different techniques to determine ESBL-producing E.coli transmission.

Conditions

  • Analysis Transmission Rate

Interventions

DIAGNOSTIC_TEST

Pulsed-field gel electrophoresis and whole genome sequencing

Comparison of the two different techniques

OTHER

Data collection

Demographic data (age, gender, hospital admission and discharge date, rooms and wards with dates of admission and discharge, hospitalization prior to current hospital stay, discharge destination, outcome, cause of death, travel history, recent hospitalization in an ESBL-high burden region, admission from another healthcare facility, admission from a long-term care facility, occupational or household contact to animals) Clinical data (date of diagnosis of ESBL-producing E. coli carriage, type of infection/colonization with ESBL- producing E. coli, comorbidities, Charlson Comorbidity Index, infectious diseases after detection of ESBL-PE, active open wounds, indwelling vascular devices, urinary catheterization) Treatment data (Immunosuppression, antibiotic therapy, concomitant medication and surgical therapy prior to and during hospital stay) Microbiological data

Sponsors & Collaborators

  • University Hospital, Basel, Switzerland

    lead OTHER

Principal Investigators

  • Sarah Tschudin Sutter, Prof. Dr. MD · University Hospital, Basel, Switzerland

Eligibility

Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-03-06
Primary Completion
2025-01-07
Completion
2025-01-07

Countries

  • Switzerland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04323553 on ClinicalTrials.gov