Study of CAR-T Therapy in Older Patients

Summary

This study is being done to find out how older patients respond to CAR-T cell therapy and how the treatment affects their quality of life. This is a quality of life study and participating in the study does not involve receiving any treatment, other than the standard treatment for participants' disease.

Conditions

• Lymphoma
• Refractory B-Cell Lymphoma
• Lymphoma, B-Cell
• DLBCL NOS
• High-grade B-cell Lymphoma
• Multiple Myeloma

Interventions

BEHAVIORAL

Activities of Daily Living/ADLs

7 activities: bathing, dressing, grooming, feeding, walking inside the home, walking outside the home, and bladder and bowel control. Participants get 2 points for each activity that is not limited at all, 1 point for limited a little, and 0 points for limited a lot. Total ADL score ranges from 0 to 14

BEHAVIORAL

Instrumental Activity of Daily Living

8 activities: telephone use, doing laundry, shopping, preparing meals, doing housework, handling own medications, handling money and finances, and transportation to visit one's doctor. Participants get 2 points for each activity that can be done without help, 1 point for needing some help, and 0 point for being unable to do. Total iADL score ranges from 0 to16.

BEHAVIORAL

Timed Up and Go

Participants are asked to get up from the chair, walk 10 feet, turn, and walk back to the char (\<10 seconds, 10-20 seconds, \>20 seconds)

BEHAVIORAL

Cognition

Mini-Cognition test: CDT and 3-word recall

BEHAVIORAL

Geriatric Depression Scale

Four yes/no questions regarding patient's psychological status. Score ranges from 0 to 4, and a score of \>/=1 is usually indicative of depression.

BEHAVIORAL

Social Support

Four 5-point Likert scale questions addressing 4 domains of social support: emotional/ informational, tangible, affectionate, and positive social interaction. Score for each item ranges from 1 to 5, and total score ranges from 4 to 20. A higher score means better social support.

BEHAVIORAL

Brief Test of Attention

assess selective auditory attention.

BEHAVIORAL

Trail Making Test

Assesses visual scanning, graphomotor speed, and set shifting.

BEHAVIORAL

Controlled Oral Word Association Test

A timed test of verbal fluency

BEHAVIORAL

Hopkins Verbal Learning Test-Revised

The HVLT-R is a test of verbal learning and recall. Scores obtained are the total number of words: 1) recalled over three trials; 2)recalled after a delay; 3) correctly recognized.

OTHER

Blood draw

collection of blood tests

Sponsors & Collaborators

• Memorial Sloan Kettering Cancer Center

  lead OTHER

Principal Investigators

• Richard Lin, MD, PhD · Memorial Sloan Kettering Cancer Center

Eligibility

Min Age

60 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2020-03-04

Primary Completion

2027-03-04

Completion

2027-03-04

Countries

• United States

Study Locations