Anti-CD22 CAR-T Cell Therapy Targeting B Cell Malignancies
NCT03262298 · Status: UNKNOWN · Phase: PHASE1/PHASE2 · Type: INTERVENTIONAL · Enrollment: 20
Last updated 2021-02-09
Summary
The study will evaluate safety and efficacy of the CD22-targeted chimeric antigen receptor modified-T cell(CAR-T) cells in the treatment of B-cell Malignancies.
Conditions
Interventions
- BIOLOGICAL
-
Anti-CD22-CAR-transduced T cells
a single dose of Anti-CD22-CAR-transduced T cells will be infusion after preconditioning.
Sponsors & Collaborators
-
Affiliated Hospital to Academy of Military Medical Sciences
lead OTHER
Principal Investigators
-
Liangding Chen, M.D. · Affiliated Hospital to Academy of Military Medical Sciences
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Max Age
- 65 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2017-08-20
- Primary Completion
- 2021-08-20
- Completion
- 2022-08-20
Countries
- China
Study Locations
More Related Trials
-
A Clinical Research of CAR T Cells Targeting CD19 Positive Malignant B-cell Derived Leukemia and Lymphoma
NCT02349698 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
Anti-CD22 Chimeric Antigen Receptor (CAR)-Modified T Cell Therapy for Relapsed Refractory B-cell Malignancies
NCT04007978 ·Status: UNKNOWN ·Phase: PHASE1
-
CAR2219 CAR-T Cells for the Treatment of R/R B Cell Leukemia and Lymphoma
NCT06834529 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
CD19/22 Bi-specific CAR-T Cell Therapy
NCT05432882 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
A Study of Humanized CD19 CAR-T Cells Therapy for Patients With Relapsed and/or Refractory B-cell ALL and B-cell NHL
NCT04532268 ·Status: RECRUITING ·Phase: EARLY_PHASE1
-
Immunotherapy With CD19 CAR γδT-cells for B-Cell Lymphoma, ALL and CLL
NCT02656147 ·Status: UNKNOWN ·Phase: PHASE1
-
Autologous Cells Derived Anti-CD19 CAR-Engineered T Cells With Concurrent BTK Inhibitor for B Cell Lymphoma
NCT05020392 ·Status: UNKNOWN ·Phase: PHASE3
-
CD19-redirected Autologous Cells (CAR-CD19 T Cells)
NCT02933775 ·Status: UNKNOWN ·Phase: PHASE1
-
CAR T Cells for Refractory B Cell Malignancy
NCT02963038 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
CD19 and CD22 Targeted CAR-T Cell Therapy for Relapsed/Refractory B Cell Leukemia and Lymphoma
NCT04649983 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
Immunotherapy With CD19 CAR T-cells for B-Cell Lymphoma, ALL and CLL
NCT02546739 ·Status: UNKNOWN ·Phase: PHASE1
-
Treatment of Relapsed and/or Chemotherapy Refractory B-cell Malignancy by Tandem CAR T Cells Targeting CD19 and CD20
NCT03097770 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Anti-CD19:TCRζ Chimeric Antigen Receptor-T Cells in the Treatment for CD19+ B Cell Lymphoma
NCT02992834 ·Status: UNKNOWN ·Phase: PHASE4
-
Anti-CD19 Chimeric Antigen Receptor (CAR)-Transduced T Cell Therapy for Patients With B Cell Malignancies
NCT03076437 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Clinical Study of Redirected Autologous T Cells With a Chimeric Antigen Receptor in Patients With Malignant Tumors
NCT03302403 ·Status: UNKNOWN ·Phase: NA
-
Chimeric Antigen Receptor (CAR)-Modified T Cell Therapy in Treating Patients With Acute Lymphoblastic Leukemia
NCT02186860 ·Status: UNKNOWN ·Phase: PHASE1
-
Immunotherapy With CD22 CAR T-cells for B-Cell Lymphoma, ALL and CLL
NCT04163575 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
Treatment of Relapsed and/or Chemotherapy Refractory B-cell Malignancy by Tandem CAR T Cells Targeting CD19 and CD22
NCT03185494 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
CD19 Chimeric Antigen Receptor (CAR)-Modified T Cell Therapy in Treating Patients With B-cell Malignancies
NCT02965092 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
Combination Transfer of αCD19-TCRz-41BB and αCD22-TCRz-41BB CAR-T Cells for B-cell Hematologic Malignancy
NCT02903810 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
CD19 CAR and PD-1 Knockout Engineered T Cells for CD19 Positive Malignant B-cell Derived Leukemia and Lymphoma
NCT03298828 ·Status: UNKNOWN ·Phase: PHASE1
-
Targeting CD19 and CD22 CAR-T Cells Immunotherapy in Patients With Relapsed or Refractory Acute B Lymphocytic Leukemia
NCT04714593 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
CD19/CD22-targeted Chimeric Antigen Receptor Engineered T Cell (CART) in B-Cell Acute Lymphoblastic Leukemia.
NCT03614858 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
Clinical Study of Chimeric Antigen Receptor T Lymphocytes (CAR-T) in the Treatment of Myeloid Leukemia
NCT04923919 ·Status: UNKNOWN ·Phase: EARLY_PHASE1
-
Memory-enriched CAR-T Cells Immunotherapy for B Cell Lymphoma
NCT02652910 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2