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Thoracic Epidural Analgesia Versus Rectus Sheath Block Versus Surgeon Infiltration With Liposomal Bupivacaine or Standard Bupivacaine for Post-Operative Pain Control After Cystectomy

NCT04300231 · Status: COMPLETED · Phase: PHASE3 · Type: INTERVENTIONAL · Enrollment: 160

Last updated 2025-02-10

Study results available
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Summary

The purpose of this study is to compare the difference between four different pain control methods in patients who will be having a cystectomy surgery (surgical removal of the bladder).

Conditions

  • Cystectomy

Interventions

DRUG

epidural bupivacaine 0.05%

Mix of epidural bupivacaine 0.05% and hydromorphone 0.05mg/ml will be given using PCEA.

DRUG

Liposomal bupivacaine

20 ml

DRUG

bupivacaine 0.125%

40 mL

DRUG

bupivacaine 0.5%

60 mL

DRUG

/hydromorphone 0.05mg/ml

Mix of epidural bupivacaine 0.05% and hydromorphone 0.05mg/ml will be given using PCEA.

DRUG

injectable saline

40 mL

Sponsors & Collaborators

  • Indiana University

    lead OTHER

Principal Investigators

  • Yar Yeap, MD · Indiana University Hospital

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2019-10-22
Primary Completion
2021-12-23
Completion
2021-12-24
FDA Drug
Yes

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04300231 on ClinicalTrials.gov