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Extending CPAP Therapy in Stable Preterm Infants to Increase Lung Growth and Function

NCT04295564 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 100

Last updated 2025-08-17

Study results available
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Summary

This is a study to see if an extra 2 weeks of continuous positive airway pressure (CPAP) in stable preterm infants in the neonatal intensive care unit (NICU) can cause increased lung growth and lung function in the infants as measured at 6 months of age by pulmonary function testing.

Conditions

  • Neonatal
  • Premature Birth
  • Respiratory Distress Syndrome

Interventions

OTHER

Additional 2 weeks of CPAP

Subjects will be randomized to an additional 2 weeks of CPAP vs. discontinuing CPAP per usual care.

Sponsors & Collaborators

  • Indiana University

    collaborator OTHER

  • National Heart, Lung, and Blood Institute (NHLBI)

    collaborator NIH

  • Cynthia McEvoy

    lead OTHER

Principal Investigators

  • Cindy McEvoy, MD · Oregon Health and Science University

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
1 Day
Max Age
12 Weeks
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-01-10
Primary Completion
2023-09-18
Completion
2024-03-15

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04295564 on ClinicalTrials.gov