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The Direct Oral Anticoagulation Versus Vitamin K Antagonist After Cardiac Surgery Trial

NCT04284839 · Status: RECRUITING · Phase: PHASE3 · Type: INTERVENTIONAL · Enrollment: 3500

Last updated 2025-09-29

No results posted yet for this study

Summary

The DANCE Trial is a multi-centre, randomized controlled trial comparing the safety of direct oral anticoagulants (DOAC) versus vitamin K antagonists (VKA) in the early period (30 days) after cardiac surgery in patients with atrial fibrillation requiring oral anticoagulation.

Conditions

  • Bleeding Post Cardiac Surgery
  • Indication for Anticoagulation

Interventions

DRUG

DOAC

Patients will receive a DOAC at doses recommended for the indication, adjusted for their renal function is required. The choice of DOAC will be at the discretion of the treating physician.

DRUG

VKA

Patients in the control group will receive VKA once daily; the individual dose will be titrated to achieve a guideline-recommended INR range.

Sponsors & Collaborators

  • Population Health Research Institute

    lead OTHER

  • Hamilton Health Sciences Corporation

    collaborator OTHER

Principal Investigators

  • Emilie Belley-Cote, MD, MSc · McMaster University

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
FACTORIAL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-07-18
Primary Completion
2027-06-30
Completion
2027-06-30

Countries

  • Australia
  • Canada
  • Germany

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04284839 on ClinicalTrials.gov