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Study in Parkinson Disease of Exercise

NCT04284436 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 370

Last updated 2026-04-13

No results posted yet for this study

Summary

This study is a Phase 3 multi-site, randomized, evaluator-masked, study of endurance treadmill exercise on changes in the Movement Disorder Society-Unified Parkinson Disease Rating Scale (MDS-UPDRS) Part III score at 12 months among persons with early stage Parkinson disease. 370 participants will be randomly assigned to 2 groups: 1)60-65% HRmax or 2)80-85% HRmax 4 times per week. The primary objective is to test whether the progression of the signs of Parkinson's disease is attenuated at 12 months in among persons who have not initiated medication for Parkinson Disease (PD) when they perform high-intensity endurance treadmill exercise.

Conditions

  • Parkinson Disease

Interventions

BEHAVIORAL

Treadmill walking

Treadmill walking 4 days per week for 30 minutes in the target heart rate

Sponsors & Collaborators

  • Northwestern University

    lead OTHER

  • University of Pittsburgh

    collaborator OTHER

  • The Parkinson Study Group

    collaborator NETWORK

Principal Investigators

  • Daniel M Corcos, PhD · Northwestern University

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
40 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-08-30
Primary Completion
2027-07-31
Completion
2028-07-31

Countries

  • United States
  • Canada

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04284436 on ClinicalTrials.gov