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Kinematic Assessment In Multiple Sclerosis

NCT04283071 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 57

Last updated 2022-03-07

No results posted yet for this study

Summary

Multiple sclerosis (MS) affects more than a 120,000 people in the United Kingdom and is the commonest neurological condition in young adults. MS causes a number of symptoms including weakness, altered sensation, pain and memory difficulties. There are different forms of MS, including relapsing-remitting MS (RRMS), primary progressive MS (PPMS) and secondary progressive MS (SPMS). Currently there are several effective treatments for RRMS, but no NICE approved treatment for SPMS. Patients with PPMS and SPMS experience a gradual progression in disability that affects individual patients differently. A number of clinical scores are used to quantify the disability in individual patients and some of these scores focus on the patients' lower limb function. In the progressive forms of MS, preservation of upper limb function becomes a more important concern for patients to maintain their quality of life.

With the advent of new treatment trials for PPMS and SPMS, it is important that clinicians and researchers are able to use accurate and quantifiable measures of upper limb function to evaluate any changes with time or response to treatment. The use of motion tracking software provides a unique opportunity to accurately track movements in real time and space and give a tailored assessment of an individual's function.

The overall aim of this study is to use established kinematic assessment tools to explore the extent and progression of upper limb dysfunction in patients with progressive MS. This aim will be achieved via the following objectives:

* Recruit a sample of participants with PPMS and SPMS from the local MS population
* Quantify the physical impairment in these participants using existing clinical scores as well the kinematic assessment tools that have been developed
* Follow-up the participants for a period of 12 months to identify and quantify any progression in their upper limb dysfunction
* Identify any factors that may influence upper limb dysfunction in this group
* Develop and evaluate the role of further kinematic techniques in this group of participants

Conditions

Interventions

DEVICE

Boxed infrared gross kinematic assessment tool

An optical motion capture system, which records the movements of infrared emitting diodes (IREDs) in three-dimensional (3D) space by triangulating images from a pair of infrared cameras

Sponsors & Collaborators

  • University of Leeds

    collaborator OTHER

  • The Leeds Teaching Hospitals NHS Trust

    lead OTHER

Principal Investigators

  • Linford Fernandes · Leeds Teaching Hospitals NHS Trust

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2019-11-07
Primary Completion
2021-10-30
Completion
2021-10-30

Countries

  • United Kingdom

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04283071 on ClinicalTrials.gov