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Non-invasive Nerve Stimulation and Cognitive Training to Improve Cognitive Performance in Healthy Older Adults

NCT04276805 · Status: ACTIVE_NOT_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 7

Last updated 2025-05-01

No results posted yet for this study

Summary

We need better tools to both enhance brain health and improve cognitive performance in healthy brain aging so that it can be delayed, reduced, or even reversed. The present proposal is designed to evaluate the pairing of cognitive training with a non-invasive neurostimulation technology that has shown promise in both increasing neuroplasticity and in enhancing cognitive performance, transcutaneous vagal nerve stimulation (tVNS).

Conditions

  • Aging

Interventions

DEVICE

Transcutaneous vagal nerve stimulation (tVNS)

a non-invasive and safe technique that transiently enhances brain GABA and noradrenaline levels.

BEHAVIORAL

cognitive training

A program of regular mental activities purported to maintain or improve one's cognitive abilities.

Sponsors & Collaborators

  • University of Arizona

    collaborator OTHER

  • University of Florida

    lead OTHER

Principal Investigators

  • John Williamson, PhD · University of Florida

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
65 Years
Max Age
90 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2020-11-17
Primary Completion
2025-10-30
Completion
2025-10-30
FDA Device
Yes

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04276805 on ClinicalTrials.gov