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GPx Activity in Subjects With Aortic Stenosis Undergoing TAVR

NCT04268160 · Status: WITHDRAWN · Type: OBSERVATIONAL

Last updated 2021-06-30

No results posted yet for this study

Summary

The aim of this project is to investigate the association of glutathione peroxidase (GPx) and severe aortic stenosis (AS), as well as the impact of transcatheter aortic valve replacement (TAVR) on GPx activity post-procedure. The burden of oxidative stress will be determined by the measurement of GPx, superoxide dismutase (SOD) and lipoprotein A (Lp(a)). We hypothesize GPx activity is reduced in participants with severe AS vs control groups and GPx activity is to increase after TAVR is performed.

Conditions

  • Glutathione Peroxidase Activity
  • Aortic Stenosis
  • Transcatheter Aortic Valve Replacement

Interventions

DIAGNOSTIC_TEST

Blood draw to measure GPx activity

Routine blood draw to measure levels of blood markers.

DIAGNOSTIC_TEST

Blood draw to measure SOD activity

Routine blood draw to measure levels of blood markers.

DIAGNOSTIC_TEST

Blood draw to measure Lp(a) levels

Routine blood draw to measure levels of blood markers.

Sponsors & Collaborators

  • University of Florida

    lead OTHER

Principal Investigators

  • Chinelo Udemgba, MD · University of Florida

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2020-11-30
Primary Completion
2021-06-15
Completion
2021-06-15

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04268160 on ClinicalTrials.gov