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The INVADE Study: INnominate Vein Approach for Central Catheterization in Difficult to cannulatE Patients

NCT04265703 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 315

Last updated 2026-03-12

No results posted yet for this study

Summary

Most recent guidelines suggest central venous access must be performed with real-time ultrasound guidance, and the most recommended site for cannulation is internal jugular vein (IJV); however, it is recognized that evidence for other sites is, at present, limited. Besides, guidelines does not account for patients with small vein cross-sectional area and/or respirophasic collapse, which can make the procedure more difficult or even impossible. The investigators aim to compare three different insertion sites for central venous access, with real-time ultrasound guidance

Conditions

  • Critical Illness

Interventions

PROCEDURE

Internal jugular vein catheterization

Catheterization of internal jugular vein with real-time (in-plane) method, with neutral neck position. Standard aseptic technique.

PROCEDURE

Subclavian vein catheterization

Catheterization of subclavian/axillary vein with infra-clavicular approach with real-time (in-plane) method, without shoulder retraction. Standard aseptic technique.

PROCEDURE

Innominate vein catheterization

Catheterization of innominate vein with supra-clavicular approach with real-time (in-plane) method, with neutral shoulder position and no shoulder retraction. Standard aseptic technique.

Sponsors & Collaborators

  • Instituto Jalisciense de Cancerologia

    collaborator OTHER_GOV

  • Hospital Civil de Guadalajara

    lead OTHER

Principal Investigators

  • Miguel Ibarra-Estrada, MD · Hospital Civil Fray Antonio Alcalde

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-02-27
Primary Completion
2027-02-28
Completion
2027-02-28

Countries

  • Mexico

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04265703 on ClinicalTrials.gov