Qualitative and Quantitative Evaluation of Vascular Flows of Radial, Ulnar and Interdigital Arterial Trees Under Normal and Pathological Conditions by 3 Tesla MRI

Summary

Allotransplants of vascularized composite tissues are subject to chronic vascular rejection, which can lead to graft loss. Currently, no imaging technique allows a reproducible quantitative exploration of the arterial trees of the hand, and therefore a satisfactory monitoring of transplants. Since 2014, flow MRI has been applied to the analysis of small-calibre arteries by the Image Processing Team at the Amiens-Picardie University Hospital. Between 2015 and 2017, several acquisitions were made in 3 patients who received facial allotransplantation, and the team recently developed a flow MRI protocol dedicated to the study of arterial trees in the hand.

The main objective is to measure vascular flows of radial, ulnar and interdigital arterial trees in normal (healthy volunteers) and pathological situations (patients with radial forearm flap reconstruction and patients with hand allotransplantation) using the specifically developed flow MRI protocol.

Conditions

• Magnetic Resonance Imaging
• Vascular Complications
• Transplantation
• Radial Artery

Interventions

OTHER

MRI acquisitions

MRI acquisitions will be performed on the ACHIEVA 3T TX DStream Philips® Research MRI of the GIE Faire Faces.

OTHER

Doppler ultrasound procedure

The Doppler ultrasound procedure will be conducted in the traditional way in the Vascular Medicine Department of the Amiens-Picardie University Hospital

Sponsors & Collaborators

• Hôpital Edouard Herriot

  collaborator OTHER

• Centre Hospitalier Universitaire, Amiens

  lead OTHER

Principal Investigators

• Stéphanie Dakpe, MD · CHU Amiens

• Jérémie Bettoni, MD · CHU Amiens

• Olivier Baledent, MD · CHU Amiens

• Marie-Antoinette Sevestre-Pietri, Pr · CHU Amiens

• Emmanuel Morelon, Pr · Hopital Edouard Herriot

• Palmira Petruzzo, MD · Hopital Edouard Herriot

Study Design

Allocation

NON_RANDOMIZED

Purpose

OTHER

Masking

SINGLE

Model

PARALLEL

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2021-09-01

Primary Completion

2028-05-31

Completion

2029-03-31

Countries

• France

Study Locations