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Desflurane,Brain Natriuretic Peptide and Cardiac Surgery

NCT04238806 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 151

Last updated 2020-01-23

No results posted yet for this study

Summary

During coronary artery bypass grafting (CABG) operations with cardiopulmonary bypass (CPB), the use of desflurane continuously or intermittently may have effects on serum brain natriuretic peptide (BNP) levels. The aim is to investigate the association between desflurane, serum BNP values, and clinical outcomes during CABG operations. In a prospective, randomized, double-blinded study, desflurane inhalational anesthesia was administered either continuously or intermittently (Group 1; n=60 versus Group 2; n=62). The preoperative and postoperative BNP levels at 24, 48 and 72 hours after surgery were collected. Outcomes were recorded.

Conditions

  • Brain Natriuretic Peptide
  • Coronary Artery Bypass Graft Surgery
  • Cardiac Surgery
  • Cardiopulmonary Bypass
  • Desflurane
  • Outcome

Interventions

DRUG

Desflurane Inhalational agent

Desflurane inhalational agent administration during the whole cardiac surgical operation with cardiopulmonary bypass versus administration of desflurane inhalational agent before and after cardiopulmonary bypass during the whole period of cardiac surgical operation.

Sponsors & Collaborators

  • Trakya University Faculty of Medicine Hospital

    collaborator UNKNOWN

  • Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital

    lead OTHER_GOV

Principal Investigators

  • Gonul Sagiroglu, MD · Trakya University, Faculty of Medicine, Edirne, Turkey

Study Design

Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2013-09-01
Primary Completion
2014-08-31
Completion
2014-09-30

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04238806 on ClinicalTrials.gov