Sleep and Cognition After Ambulatory Hip and Knee Arthroplasty

Summary

Sleep and rest are key elements in postoperative rehabilitation and recovery. There are complex relations between major surgery, sleep disturbance and complications. Major surgery leeds to severe postoperative sleep disturbances, initially reducing REM sleep time and disturbing the remaining sleep stages. Major surgery is again a risk factor for postoperative delirium and other cognitive impairment. The underlying mechanisms includes pain, opioid medication, sleep disturbances and neuroinflammation, along with external factors as noise during hospitalisation. The physiologic stress from sleep disturbances and sleep deprivation is associated with blood-brain barrier impairment, inflammation, decreased restitution, altered nociceptive function. Likewise, undiagnosed and untreated sleep apnea is a risk for postoperative complications and is itself affected by anesthesia and some analgesics (i.a. opioids).

Fast-track surgery development has led to restitution period shortening, optimized pain management reducing opioid use, postoperative inflammatory stress response reduction and less delirium. Evolution of hip and knee arthroplasty(THA/TKA), organisation, optimized pain management and pharmacologic modification of inflammatory response by high dose steroid has permitted to perform these surgeries in an outpatient setting.

Previous studies of fast-track THA/TKA using multimodal opioid-sparring analgesia, however neither using high dose steroids nor in an out patient setting, have demonstrated REM sleep period reduction from a normal range of 18% preoperatively to 1% postoperatively. However, changes in sleep architecture after THA/TKA in at setting attempting to minimise abnormal sleep by means of ambulatory surgery added to perioperative reduction of inflammatory response to surgery, pain and opioid use by high dose steroid, haven't been studied.

The purpose of this study is to investigate how much an optimized ambulatory THA/TKA , reducing pain and inflammatory response to surgery and opioid use by high doses steroid can conserve the preoperative sleep architecture.

Conditions

• Sleep Disturbance
• Delirium
• Arthroplasty Complications

Sponsors & Collaborators

• Kehlet, Henrik, M.D., Ph.D.

  collaborator INDIV

• Nicolai Bang Foss

  collaborator UNKNOWN

• Poul Jenum

  collaborator UNKNOWN

• Anders Troelsen

  collaborator UNKNOWN

• Kirill Gromov

  collaborator UNKNOWN

• Mette Grentoft

  collaborator UNKNOWN

• Henning Piilgaard Hansen

  collaborator UNKNOWN

• Hvidovre University Hospital

  lead OTHER

Principal Investigators

• Henrik Kehlet, Dr.med,Phd · Rigshospitalet, Denmark

Eligibility

Min Age

18 Years

Max Age

80 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2020-03-31

Primary Completion

2020-07-31

Completion

2020-07-31

Countries

• Denmark

Study Locations