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Stopping Maintenance Therapy in People With Multiple Myeloma in MRD-Negative Remission

NCT04221178 · Status: ACTIVE_NOT_RECRUITING · Type: OBSERVATIONAL · Enrollment: 50

Last updated 2026-02-10

No results posted yet for this study

Summary

This study will test whether stopping maintenance therapy in people with multiple myeloma in MRD-negative remission has the same effect on disease control as continuing this therapy. The study will look at whether people currently on maintenance therapy can safely stop this treatment and continue with active surveillance instead while keeping their MRD-negative remission status for at least 1 year.

Conditions

  • Plasma Cell Myeloma

Interventions

OTHER

Cessation of continuous matinenace therapy

Cessation of maintenance therapy for participants in sustained MRD-negative remission while under careful observation

Sponsors & Collaborators

Principal Investigators

  • Neha Korde, MD · Memorial Sloan Kettering Cancer Center

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-01-03
Primary Completion
2027-01-03
Completion
2027-01-03

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04221178 on ClinicalTrials.gov