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Taste of Medicines in Children

NCT04220918 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 136

Last updated 2023-03-06

No results posted yet for this study

Summary

Some but not all children will refuse to take medicine because of its taste, which can lead to substantial worsening of disease, antibiotic resistance, increased health care costs, and even death. The investigators are systematically assessing individual variation in the taste of liquid clindamycin among genotyped pediatric patients prescribed clindamycin for standard of care treatment, to determine whether (1) genetic variation underlies differences in taste ratings of the antibiotic; (2) initial taste responses, genetics, or both predict likelihood of side effects and medication non-adherence.

Conditions

  • Medication Adherence
  • Medication Reaction

Sponsors & Collaborators

  • National Institute on Deafness and Other Communication Disorders (NIDCD)

    collaborator NIH

  • Monell Chemical Senses Center

    collaborator OTHER

  • Children's Hospital of Philadelphia

    lead OTHER

Principal Investigators

  • Elizabeth D Lowenthal, MD, MSCE · Children's Hospital of Philadelphia

  • Julie A Mennella, PhD · Monell Chemical Senses Center

Eligibility

Min Age
3 Years
Max Age
12 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-02-14
Primary Completion
2022-09-30
Completion
2023-02-01

Countries

  • United States

Study Locations

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Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04220918 on ClinicalTrials.gov