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Association Between SNP of SP-D and Susceptibility and Prognosis of Infectious Keratitis

NCT04213313 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 145

Last updated 2020-01-07

No results posted yet for this study

Summary

This study explores the association between single nucleotide polymorphism (Met11Thr) of surfactant protein D(SP-D) and susceptibility and prognosis of infectious keratitis.Met11Thr of SP-D of patients with keratitis and normal controls were compared.Allele and genotype frequencies of patients with keratitis and normal controls were determined by polymerase chain reaction with sequence specific primers(PCR-SSPs) .SP-D gene polymorphism of patients with keratitis and normal controls was detected by Sanger sequencing

Conditions

  • Infectious Keratitis

Interventions

DRUG

Treatment of bacterial keratitis

0.3% Levofloxacin Eye Drops or 0.3% Tobramycin Eye Drops QID

DRUG

Treatment of fungal keratitis

1% Fluconazole Eye Drops or 0.25% Amphotericin B Eye Drops QID

DRUG

Treatment of viral keratitis

0.1% Acyclovir eye drops QID ，Ganciclovir gel QN，Famiclovir tablets 0.25g TID

DIAGNOSTIC_TEST

corneal scraping

culture and sensitivity of corneal ulcerated infiltrating edge tissue

OTHER

Sequencing

polymerase chain reaction with sequence specific primers(PCR-SSP) and Sanger sequencing

Sponsors & Collaborators

  • Second Affiliated Hospital, School of Medicine, Zhejiang University

    lead OTHER

Principal Investigators

  • Tao Jiang · Second Affiliated Hospital, School of Medicine, Zhejiang University

Eligibility

Min Age
18 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2016-10-01
Primary Completion
2018-06-30
Completion
2019-06-30

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04213313 on ClinicalTrials.gov