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Comparison of Pre- vs Post-dilution Haemodiafiltration in Children

NCT04210154 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 25

Last updated 2023-08-22

No results posted yet for this study

Summary

Cardiovascular morbidity and mortality are increased in children on conventional haemodialysis. Haemodiafiltration (HDF) is a newer type of dialysis which has two main types (post-dilution and predilution HDF). Post-dilution HDF is associated with better vascular health, blood pressure and growth in children. Furthermore, pre-dilution HDF is shown to remove a wider spectrum of uremic toxin compared to post-dilution HDF in adults. The investigators need more data to define the optimum dialysis modality for children.

Conditions

  • Haemodiafiltration

Interventions

DEVICE

Haemodiafiltration

pre-dilution and post-dilution Haemodiafiltration

Sponsors & Collaborators

  • Istanbul University

    collaborator OTHER

  • Heidelberg University

    collaborator OTHER

  • Hospices Civils de Lyon

    collaborator OTHER

  • Great Ormond Street Hospital for Children NHS Foundation Trust

    lead OTHER

Principal Investigators

  • Rukshana Shroff, MD PhD · Great Ormond Street Children's Hospital, London, UK

  • Salim Caliskan, Prof Dr · Istanbul University, Cerrahpasa Medical Faculty, Istanbul, Turkey

  • Nur Canpolat, Assoc Prof · Istanbul University, Cerrahpasa Medical Faculty, Istanbul, Turkey

  • Ayse Agbas, MD · University of Health Sciences, Haseki Education and Research Hospital, Istanbul, Turkey

Eligibility

Min Age
5 Years
Max Age
20 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-02-01
Primary Completion
2023-12-31
Completion
2024-12-31

Countries

  • France
  • Germany
  • Turkey (Türkiye)
  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04210154 on ClinicalTrials.gov