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Determinants of Repeated Spontaneous Miscarriages and Unexplained Fetal Deaths

NCT04207814 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 200

Last updated 2026-03-20

No results posted yet for this study

Summary

The DEFI-1 study recruited 625 women witnesses and 299 of their spouses. With regard to case couples, 271 cases were recruited from the spontaneous repeated miscarriages (SRM) subgroup (≥3 spontaneous miscarriage (SM) from trimester 1 of pregnancy) and 93 from the unexplained fetal death in utero (FDIU) subgroup from trimesters 2 and 3 of pregnancy.

The main objective of the DEFI 2 study is to increase the number of case-pairs in these 2 particular subgroups to replicate the results of the genetic determinants highlighted from cases and controls with extreme phenotypes and obtain a sufficient number of women with FDIUs to identify specific determinants.

Conditions

  • Repeated Spontaneous Miscarriages
  • Fetal Deaths in Utero

Interventions

BIOLOGICAL

biological sample

biological samples will be taken from the subjects included

Sponsors & Collaborators

  • University Hospital, Brest

    lead OTHER

Principal Investigators

  • Elisabeth Pasquier, MD · Brest University Hospital in France

Study Design

Allocation
NA
Purpose
OTHER
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Max Age
40 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-10-05
Primary Completion
2057-10-05
Completion
2057-10-05

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04207814 on ClinicalTrials.gov