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Neurocognitive Benefits of a Weight Management Program

NCT04202133 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 61

Last updated 2025-02-10

Study results available
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Summary

This study will assess whether weight loss induced through diet and physical activity can change neural responses to high- and low-calorie food images. In addition, it will evaluate whether weight loss can improve neural function when performing the N-back task, a measure of working memory. Findings will address notable gaps in the literature by testing whether a scalable weight loss intervention can help protect and improve neurocognitive functioning and brain health in individuals with obesity. This study will also provide important information about the effects of weight loss on neuroplasticity in brain regions crucial for memory and cognitive functioning, which will help to inform future interventions aimed at promoting brain health.

Conditions

  • Overweight and Obesity

Interventions

BEHAVIORAL

WW (formerly Weight Watchers)

The WW intervention will consist of weekly group workshops for 16 weeks with WW Coaches and Guides.

BEHAVIORAL

Waitlist

The waitlist group will have a 16-week waitlist period. After the waitlist period, they will be offered the WW intervention

Sponsors & Collaborators

Principal Investigators

  • Ariana M. Chao, PhD, CRNP · University of Pennsylvania

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
60 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2019-11-20
Primary Completion
2021-04-02
Completion
2021-07-20

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04202133 on ClinicalTrials.gov