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Muscle Structure, Function and Gait in dHMN

NCT04193228 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 11

Last updated 2023-11-28

No results posted yet for this study

Summary

Distal Hereditary Motor Neuropathy (dHMN) is a rare inherited neuromuscular disorder. It is characterised by distal weakness. The condition usually manifests in the second decade of life and progresses slowly. Though patients usually have a normal lifespan it is a disabling condition and most eventually need aids to walk. In order to improve walking quality in patient with dHMN, research is needed to understand the impairments that lead to altered gait patterns, and to develop interventions to correct walking gait conservatively.

In this proposed trial our goal is to explore the relationships between muscle structure, function and gait patterns for people with Distal Hereditary Motor Neuropathy. Over 12 months, muscle changes in dHMN are going to be observed in terms of structure and function using MRI, myometry and 3D motion analysis. In addition, the effect of a 16 weeks exercises program on muscle structure and function in dHMN is going to be measured by the same observational methods. To address walking gait directly in dHMN, gait patterns with and without wearing carbon fibre ankle foot orthoses (AFO)will be measured using 3D motion analysis.

Conditions

  • Distal Hereditary Motor Neuropathy, Type II
  • Distal Hereditary Motor Neuropathy, Type V
  • Distal Hereditary Motor Neuronopathy Type I
  • Distal Hereditary Motor Neuronopathy Type VI

Interventions

DEVICE

Carbon Fibre Ankle Foot Orthosis

Off teh shelf carbon fibre ankle foot orthoses worn bilaterally

BEHAVIORAL

Exercise

Ankle muscle strength training

Sponsors & Collaborators

  • University College London Hospitals

    lead OTHER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2021-11-02
Primary Completion
2023-11-01
Completion
2023-11-27

Countries

  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04193228 on ClinicalTrials.gov