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Correlation of NLRP3 With Cognitive Dysfunction Early After Heart Valve Replacement Surgery

NCT04191642 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 75

Last updated 2021-09-01

No results posted yet for this study

Summary

The investigators decided to assess the prognostic value of NLRP3 inflammasome level in early after heart valve replacement surgery and whether it was related to postoperative cognitive dysfunction. Study population included 90 subjects. Neuropsychological tests were administrated one day before surgery and seven days after surgery. Before induction of anesthesia, before the end of the operation, 7 days after the operation, peripheral venous blood was sampled to measure IL-1B, IL-18 and NLRP3 inflammatory protein expression in peripheral blood monocytes. Analyze the data and draw conclusions.

Conditions

  • Inflammasomes
  • Cognitive Dysfunction
  • Pyrin Domain-Containing 3 Protein
  • Postoperative Complications

Sponsors & Collaborators

  • General Hospital of Ningxia Medical University

    lead OTHER

Principal Investigators

  • Gang Ma, doctor · Department of Anesthesiology General Hospital of Ningxia Medical University

Eligibility

Min Age
60 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2019-04-01
Primary Completion
2021-01-30
Completion
2021-01-30

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04191642 on ClinicalTrials.gov