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Study of Leukocyte Immunophenotype and the Lipid Transport System as Predictive Biomarkers of Severe Bacterial Infections

NCT04178915 · Status: ENROLLING_BY_INVITATION · Type: OBSERVATIONAL · Enrollment: 100

Last updated 2025-02-11

No results posted yet for this study

Summary

Current study evaluates the relationship between cell immunity and lipid transport systems in patients with severe bacterial infections (on the model of pneumonia, infective endocarditis, sepsis) in order to develop new methods for predicting the course and outcome of severe bacterial infections.

Conditions

  • Sepsis
  • Infective Endocarditis
  • Pneumonia, Bacterial

Interventions

DIAGNOSTIC_TEST

Bood leukocyte subsets

Determination of blood leukocyte subpopulations, myeloid suppressor cells of various origins, type 2 congenital lymphoid cells, depleted T cells, CD45RA+ CD45RB+ CD62L-IRC, T-cell differentiation stages (naive - memory cells - effector - terminally differentiated effectors), B cells (CD5+ B1 cells, CD11c+ ABC, differentiation stages: immature - naive - isotype-unswitched memory cells - isotype-switched memory cells - plasmoblast)

DIAGNOSTIC_TEST

The cholesterol content of the cell membrane of T-cells and monocytes

The cholesterol content of the cell membrane of T-cells and monocytes with flow cytometry analysis

Sponsors & Collaborators

  • Belarusian State Medical University

    collaborator OTHER

  • The Republican Research and Practical Center for Epidemiology and Microbiology

    lead OTHER

Principal Investigators

  • Elena Fomina, Dr · Head of the laboratory, RSPCEM

Eligibility

Min Age
18 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2019-07-01
Primary Completion
2025-12-31
Completion
2025-12-31

Countries

  • Belarus

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04178915 on ClinicalTrials.gov