Study to Test the Safety and Tolerability of PF-07062119 in Patients With Selected Advanced or Metastatic Gastrointestinal Tumors.
NCT04171141 · Status: TERMINATED · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 79
Last updated 2025-01-16
Summary
A phase 1, open-label, dose escalation and expansion study of PF-07062119 in patients with selected advanced or metastatic gastrointestinal tumors
Conditions
- Gastrointestinal Tumors
- Colorectal Adenocarcinomas
- Gastric Adenocarcinomas
- Esophageal Adenocarcinomas
Interventions
- DRUG
-
PF-07062119
PF-07062119
- DRUG
-
Anti-PD1
Anti-PD1 PF-06801591
- DRUG
-
Anti-VEGF
Anti-VEGF IV (bevacizumab)
Sponsors & Collaborators
- lead INDUSTRY
Principal Investigators
-
Pfizer CT.gov Call Center · Pfizer
Study Design
- Allocation
- NON_RANDOMIZED
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SEQUENTIAL
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2019-11-19
- Primary Completion
- 2023-11-28
- Completion
- 2023-11-28
- FDA Drug
- Yes
Countries
- United States
- Australia
- Japan
Study Locations
More Related Trials
-
Pembrolizumab (MK-3475) Plus Chemotherapy Versus Placebo Plus Chemotherapy in Participants Gastric or Gastroesophageal Junction (GEJ) Adenocarcinoma (MK-3475-859/KEYNOTE-859)-China Extension
NCT04859582 ·Status: WITHDRAWN ·Phase: PHASE3
-
A Safety and Efficacy Study in Patients With Gastric Cancer
NCT00400179 ·Status: COMPLETED ·Phase: PHASE3
-
Study of S-1 and Oxaliplatin as Neoadjuvant Chemotherapy for Locally Advanced Gastric Cancer
NCT01090505 ·Status: UNKNOWN ·Phase: PHASE2
-
Efficiency of XELOX Neoadjuvant Chemotherapy in Gastric Cancer
NCT01665274 ·Status: TERMINATED ·Phase: PHASE2
-
PD-1 Antibody(SHR-1210) Plus Apatinib Combined With POF in Advanced Gastric Cancer
NCT04174339 ·Status: UNKNOWN ·Phase: NA
-
A Study of ARQ 197 Versus Investigator's Choice of Second-Line Chemotherapy in Patients With Locally Advanced or Metastatic Gastric Cancer Who Have Progressive Neoplastic Disease Following Treatment With One Prior Chemotherapy Regimen
NCT01070290 ·Status: WITHDRAWN ·Phase: PHASE2
-
Study of Oxaliplatin, Calcium Folinate, and 5-Fluorouracil as Neoadjuvant Chemotherapy for Resectable Advanced Gastric Cancer
NCT00591045 ·Status: UNKNOWN ·Phase: PHASE2
-
Phase 1 Dose Escalation Study of CGX1321 in Subjects With Advanced Gastrointestinal Tumors
NCT03507998 ·Status: UNKNOWN ·Phase: PHASE1
-
Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy, Phase 1 Study of CMG901
NCT04805307 ·Status: COMPLETED ·Phase: PHASE1
-
Neoadjuvant Therapy for the Treatment of Gastroesophageal Junction and Gastric Cancers
NCT05296005 ·Status: WITHDRAWN ·Phase: PHASE1
-
Study of Modified Docetaxel, Cisplatin, and Fluorouracil (mDCF) in Unresectable or Metastatic Gastric and Gastroesophageal Junction Adenocarcinoma
NCT00515411 ·Status: COMPLETED ·Phase: PHASE2
-
Neoadjuvant of Sintilimab Combined Weekly Metronomic Chemotherapy (PLOF) for Resectable Locally Advanced Gastric Cancer
NCT06054906 ·Status: RECRUITING ·Phase: PHASE2
-
PD-1 Antibody + XELOX in 1st Line Serum A-fetoprotein (AFP)-Elevated Gastric or Gastroesophageal Junction Adenocarcinoma
NCT04098796 ·Status: UNKNOWN ·Phase: PHASE2
-
A Phase I Study of S-1 Plus Irinotecan and Oxaliplatin in Advanced Gastrointestinal Malignancy
NCT00506207 ·Status: UNKNOWN ·Phase: PHASE1
-
A Study of Pembrolizumab (MK-3475) in Participants With Recurrent or Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma (MK-3475-059/KEYNOTE-059)
NCT02335411 ·Status: COMPLETED ·Phase: PHASE2
-
Sequential Anti-Angiogenic Therapy After Immunotherapy in Advanced Biliary Tract Cancer
NCT07025174 ·Status: RECRUITING ·Phase: PHASE2
-
Nab-paclitaxel Plus PD-1 Inhibitor Versus Nab-paclitaxel As Second-line Treatment in Advanced Gastric Cancer
NCT04294784 ·Status: TERMINATED ·Phase: PHASE2
-
Nab-paclitaxel Plus Camrelizumab and S-1 Conversion Therapy for Gastric Cancer With Positive Exfoliative Cancer Cells
NCT05410847 ·Status: UNKNOWN ·Phase: PHASE2
-
A Study of the Safety and PK of PCS6422 (Eniluracil) with Capecitabine in Patients with Advanced, Refractory GI Tract Tumors
NCT04861987 ·Status: COMPLETED ·Phase: PHASE1
-
PDR001 Plus Imatinib for Metastatic or Unresectable GIST
NCT03609424 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
A Phase II Study of Oxaliplatin in Association With 5FU and Folinic Acid in the Treatment of Subjects With Non-Surgical or Advanced Metastatic Gastric Cancer
NCT00611507 ·Status: COMPLETED ·Phase: PHASE2
-
EP0057 in Combination With Olaparib in Relapsed Advanced Gastric Cancer and Small Cell Lung Cancer
NCT05411679 ·Status: WITHDRAWN ·Phase: PHASE2
-
BGB A317 in Combination With Chemotherapy as First-Line Treatment in Adults With Inoperable, Locally Advanced or Metastatic Esophageal, Gastric, or Gastroesophageal Junction Carcinoma
NCT03469557 ·Status: COMPLETED ·Phase: PHASE2
-
POF Versus FOLFOX Plus IP Paclitaxel in AGC
NCT04155671 ·Status: UNKNOWN ·Phase: PHASE2
-
A Study of Onartuzumab (MetMAb) in Combination With mFOLFOX6 in Patients With Metastatic Human Epidermal Growth Factor Receptor 2 (HER2) Negative Gastroesophageal Cancer
NCT01590719 ·Status: COMPLETED ·Phase: PHASE2