Effect of Multimodal Opioid-free Anesthesia on Return of Bowel Function in Laparoscopic Colorectal Surgery

Summary

The objective of this study is to determine if an opioid-free general anesthetic (OFA) technique utilizing lidocaine, ketamine, dexmedetomidine and magnesium reduce postoperative opioid consumption and speed return of bowel function in patients undergoing elective, laparoscopic, colorectal surgery compared to traditional opioid-containing general anesthetic techniques. It is hypothesized that this intraoperative OFA regimen will reduce postoperative opioid consumption, and expedite return of bowel function in this population.

Conditions

• Anesthesia
• General Anesthesia
• Analgesics, Opioid
• Opioid Free Anesthesia
• Postoperative Ileus
• Colorectal Surgery
• Laparoscopic Surgery
• Analgesia
• Dexmedetomidine
• Lidocaine
• Ketamine

Interventions

DRUG

Acetaminophen, Gabapentin

975 mg, 300 mg

DRUG

Acetaminophen, Gabapentin

975 mg, 300 mg

DRUG

Lidocaine 1% Injectable Solution, Dexmedetomidine, Ketamine

1.5 mg/kg, 0.5 mcg/kg, 0.5 mg/kg

DRUG

Dexamethasone, Ondansetron

6 mg, 4 mg

DRUG

Sevoflurane, Lidocaine 2% Injectable Solution, Ketamine, Dexmedetomidine, Magnesium Sulfate

Dose titrated to effect, 1.5 mg/kg/hr, 0.15 mg/kg/hr, 0.3 -1 mcg/kg/hr (titrated to effect), 30 mg/kg bolus over 30 minutes

DRUG

Lidocaine 1% Injectable Solution, Sufentanil

0.5 mg/kg, 0.25-0.5 mcg/kg (titrated to effect)

DRUG

Sevoflurane, Sufentanil

Dose titrated to effect, As needed (dose at anesthesiologist's discretion)

Sponsors & Collaborators

• University of Saskatchewan

  lead OTHER

Study Design

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

TRIPLE

Model

PARALLEL

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2021-05-15

Primary Completion

2024-07-30

Completion

2024-08-01

Countries

• Canada

Study Locations