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Analgesics in the Pre-hospital Setting: Implications on Hemorrhage Tolerance - Morphine

NCT04138615 · Status: COMPLETED · Phase: PHASE1/PHASE2 · Type: INTERVENTIONAL · Enrollment: 44

Last updated 2023-01-12

Study results available
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Summary

We are examining how morphine (a commonly used pain medication) will alter responses to simulated blood loss in humans. To simulate blood loss in our research laboratory, participants will complete a test with their lower body in a custom-designed vacuum chamber for a brief period of time.

Conditions

  • Healthy

Interventions

DRUG

Morphine

Subjects will receive Morphine while the effects of this drug on tolerance to a hemorrhagic insult will be assessed.

OTHER

Placebo

Subjects will receive saline while the effects of this drug on tolerance to a hemorrhagic insult will be assessed.

Sponsors & Collaborators

  • University of Texas Southwestern Medical Center

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
45 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2019-11-12
Primary Completion
2022-01-04
Completion
2022-01-04
FDA Drug
Yes

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04138615 on ClinicalTrials.gov