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An International, Multicenter, Prospective Registry on Post-traumatic Long Bones Defects

NCT04112992 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 600

Last updated 2025-08-29

No results posted yet for this study

Summary

Long bone defect (LBD) is defined as a focalized loss of bone tissue in any long bone of the upper or lower extremity. Long bone defects are a complex problem, that may arise as a complication of many different pathologies, such as trauma, tumors or infection. Whereas post-traumatic defects are the largest group.

Reports estimate that there are almost 4 million bone grafting procedures worldwide per year. However, limb reconstruction in the context of a bony defect is challenging and up to date there is little evidence and treatment recommendations.

In a multi-national approach, the aim of this project is to set up an international, multicenter registry to gather information and details on prevalence or incidence, current treatments, complications and outcome.

Conditions

  • Limb Fracture
  • Bone Loss

Interventions

PROCEDURE

Any treatment that is used for a defect of any long bone

Any treatment that is used for a defect of any long bone. All treatments are based on individual clinician's judgement and the patient characteristics. The registry does not dictate any specific treatment.

Sponsors & Collaborators

  • AO Innovation Translation Center

    lead OTHER

Principal Investigators

  • Hans-Christoph Pape, MD · University Hospital Zurich Department of Trauma Surgery

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-07-03
Primary Completion
2028-05-31
Completion
2029-03-30

Countries

  • United States
  • Australia
  • Brazil
  • Chile
  • Colombia
  • Germany
  • India
  • Netherlands
  • South Africa
  • South Korea
  • Switzerland
  • Ukraine
  • United Kingdom
  • Venezuela

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04112992 on ClinicalTrials.gov