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Penehyclidine and Postoperative Nausea and Vomiting After Bimaxillary Surgery

NCT04112771 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 243

Last updated 2020-06-30

No results posted yet for this study

Summary

Postoperative nausea and vomiting (PONV) are common complications after surgery. Patients undergoing orthognathic surgery are reported to have a high rate of PONV, especially those undergoing bimaxillary surgery. Activation of cholinergic system plays an important role in the development of PONV. Penehyclidine is an muscarinic antagonists which selectively block M1 and M3 receptors and is commonly used to decrease oral secretion. The purpose of this retrospective cohort study is to investigate whether use of penehyclidine is associated with a reduced risk of PONV in patients undergoing bimaxillary surgery.

Conditions

  • Penehyclidine
  • Postoperative Nausea and Vomiting
  • Bimaxillar Surgery

Interventions

DRUG

Penehyclidine hydrochloride

Penehyclidine hydrochloride was administered before anesthesia induction.

OTHER

No penehyclidine hydrochloride

Penehyclidine hydrochloride was not administered before anesthesia induction.

Sponsors & Collaborators

  • Peking University Hospital of Stomatology

    collaborator OTHER

  • Peking University First Hospital

    lead OTHER

Principal Investigators

  • Dong-Xin Wang, MD, PhD · Peking University First Hospital

Eligibility

Min Age
16 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2019-10-07
Primary Completion
2019-12-30
Completion
2019-12-30

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04112771 on ClinicalTrials.gov