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Compression Hosiery to Avoid Post-Thrombotic Syndrome

NCT04103112 · Status: TERMINATED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 152

Last updated 2024-03-07

Study results available
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Summary

Patients with a deep vein thrombosis (DVT) may develop long-term symptoms, e.g. lifelong leg pain, skin changes and occasionally ulceration, known as post-thrombotic syndrome (PTS). This affects about half of people with a history of DVT.

This randomised study aims to show whether the regular use of a compression stocking after DVT in the leg, prevents long-term pain, swelling and ulceration. Currently small trials show varied results and a large trial is required to answer the question.

Conditions

  • Deep Vein Thrombosis
  • Deep Vein Thrombosis Leg
  • Post Thrombotic Syndrome

Interventions

DEVICE

Graduated compression stocking

Compression stockings have been used safely in the UK for about 50 years. They contain an elastic fibre designed to fit tightly around the legs. These specialist stockings are tighter around the ankle, with the level of compression gradually decreasing up the garment. The pressure created by the stockings helps blood flow up the leg, allowing blood to flow freely to the heart and not pool in the leg which can result in pain and swelling.

Sponsors & Collaborators

  • University of Edinburgh

    collaborator OTHER

  • Universidad de Granada

    collaborator OTHER

  • University College, London

    collaborator OTHER

  • University of Manchester

    collaborator OTHER

  • Imperial College London

    lead OTHER

Principal Investigators

  • Alun H Davies · Imperial College London

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-03-05
Primary Completion
2022-12-31
Completion
2022-12-31

Countries

  • United Kingdom

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04103112 on ClinicalTrials.gov