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Improving White Matter Integrity With Thyroid Hormone

NCT04098991 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 5

Last updated 2020-04-10

No results posted yet for this study

Summary

Animal studies have shown that thyroid hormone can improve white matter integrity after damage to myelin, which insulates and protects nerves. It is currently unknown whether this type of repair can occur in humans. The purpose of the proposed study is to examine the impact of thyroid hormone on white matter integrity in humans using two complementary, state-of-the-art neuroimaging techniques: high angular diffusion imaging and multicomponent relaxometry.

Conditions

Interventions

DRUG

Levothyroxine

All participants will be treated for their hypothyroidism according to the standard of care as reflected in recent guidelines from the American Thyroid Association.

Sponsors & Collaborators

  • National Institute of Neurological Disorders and Stroke (NINDS)

    collaborator NIH

  • University of Illinois at Chicago

    lead OTHER

Principal Investigators

  • Olusola A Ajilore, MD/PhD · University of Illinois at Chicago

Eligibility

Min Age
21 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2017-11-08
Primary Completion
2019-11-08
Completion
2019-11-08
FDA Drug
Yes

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04098991 on ClinicalTrials.gov