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An Observational Study Designed to Elucidate the Pathways by Which Inflammation Contributes to Anaemia in Sick Rural African Children From 6 Months to 36 Months

NCT04095884 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 200

Last updated 2020-01-09

No results posted yet for this study

Summary

The Investigator have previously shown that hepcidin is up-regulated even by low levels of inflammation and, according to our prior stable isotope studies, is predicted to block iron absorption. In this follow-up observational study, the investigator aim to characterise the relationship between infections, acute inflammation, hepcidin and iron iron deficiency anaemia in rural African children. The Investigator will study 200 sick children (6-36 months of age) living in the rural region of West Kiang.

The Investigator will:

1. Recruit 50 sick febrile children in each of 4 categories; Upper Respiratory tract infections, Lower respiratory tract infections (pneumonia), Urinary tract infections, gastroenteritis.
2. Assess iron absorption and its relationship to iron and anaemia status, inflammation, EPO, erythroferrone and hepcidin.

Conditions

  • Iron Deficiency, Anaemia in Children

Interventions

PROCEDURE

blood sampling

observational study and no intervention will be given. only blood samples collected and treated with iron supplements

Sponsors & Collaborators

  • University of Oxford

    collaborator OTHER

  • London School of Hygiene and Tropical Medicine

    lead OTHER

Eligibility

Min Age
6 Months
Max Age
36 Months
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2019-07-17
Primary Completion
2023-01-31
Completion
2023-04-30

Countries

  • The Gambia

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04095884 on ClinicalTrials.gov