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The Role of microRNA-210 in Regulating Oxidative Stress in Patients With PAD

NCT04089943 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 230

Last updated 2026-02-23

No results posted yet for this study

Summary

MicroRNA-210 (miR-210) can be a potential therapeutic target of patients with peripheral artery disease (PAD). Recent evidence suggests the role of miR-210 and oxidative stress in the pathophysiology of PAD and its association with mitochondrial function, oxidative metabolism, walking distances and quality of life. The protocol evaluates the mechanisms which miR-210 regulates oxidative stress and provides evidence of potential therapeutic strategies.

Conditions

  • Peripheral Arterial Disease
  • Vascular Diseases, Peripheral
  • Arterial Occlusive Diseases
  • Atherosclerosis

Interventions

PROCEDURE

Revascularization operation

Participants will be randomized into an endovascular or open bypass procedure.

OTHER

Control group

Healthy non-PAD participants will be recruited for the study.

Sponsors & Collaborators

  • National Institute on Aging (NIA)

    collaborator NIH

  • University of West Florida

    lead OTHER

Principal Investigators

  • Panagiotis Koutakis, PhD · University of West Florida

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
30 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2019-09-15
Primary Completion
2024-08-29
Completion
2025-08-25

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04089943 on ClinicalTrials.gov