MedTrace Logo

The Efficacy of Low-load Blood Flow Restricted Resistance Before TKR

NCT04081493 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 86

Last updated 2024-09-19

No results posted yet for this study

Summary

The primary aim of this study is to investigate the efficacy of 8 weeks of Low-load blood flow restricted exercise (BFRE) compared to receiving standard care only (no preoperative training) before total knee replacement (TKR) on postoperative 30-seconds chair stand test (30s-CST). We hypothesize that 8 weeks of preoperative BFRE will increase chair stand performance 3 months postoperatively. Secondary aims are to investigate the efficacy of 8 weeks of preoperative BFRE compared to receiving standard care only on changes in muscle strength 3 months after TKR and investigate associations to functional capacity and quality of life. Furthermore, it will be investigated if 8 weeks of BFRE induces muscle hypertrophy and increases satellite cell and myonuclei content of the vastus lateralis muscle.

Conditions

  • Total Knee Replacement

Interventions

OTHER

Low-load blood flow restricted exercise

Leg press and knee extension exercise 3 times per week for 8 weeks. Repetition scheme: 30-15-15-until exhaustion interspaced by 30 sec rest. 5 min "free-flow" rest between exercises

Sponsors & Collaborators

  • Horsens Hospital

    collaborator OTHER

  • Regionshospitalet Silkeborg

    collaborator OTHER

  • University of Aarhus

    lead OTHER

Principal Investigators

  • Stian L Jørgensen, MSc · Department of Physio and Occupational Therapy, Horsens Regional Hospital

  • Inger Mechlenburg, DMSc, PhD · Department of Clinical Medicine, Aarhus University, Denmark

  • Per Aagaard, Prof, PhD · Department of Sports Science and Clinical Biomechanics

  • Marie B Bohn, PhD · Department of Orthopaedic Surgery

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
50 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2019-09-17
Primary Completion
2023-06-10
Completion
2024-04-01

Countries

  • Denmark

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04081493 on ClinicalTrials.gov