Blood Flow Restriction Exercise Study

Summary

This pilot study will investigate the effects of blood flow restriction (BFR) exercise for up to 4-6 weeks prior to total knee arthroplasty (TKA) surgery in older patients to measure clinical outcomes such as strength, lower extremity function, and pain.

Conditions

• Osteoarthritis, Knee

Interventions

DEVICE

Strength testing

Test the strength of subject's lower extremity muscles on the dynamometer system

BEHAVIORAL

Short Physical Performance Battery (SPPB)

The SPPB is a timed short distance walk, repeated chair stands, and balance test that measures lower extremity function.

BEHAVIORAL

Six-minute walk (SMW)

Subjects walk back and forth along a 100-ft hallway for six minutes after instructions to complete as many laps as possible.

BEHAVIORAL

Numerical pain scale

Measure pain using an 11-point numerical pain scale.

BEHAVIORAL

Self-assessed function

Using the Late Life Function and Disability Instrument.

PROCEDURE

Muscle biopsies

During the course of the surgery two small muscle biopsies from the quadriceps muscle of the operative leg will be collected.

DEVICE

Determination of 1 Repetition Maximum (1-RM)

Following the warm-up, subjects will attempt to complete one repetition of the leg press exercise at progressively greater resistance until a full repetition can no longer be performed. The weight of the last complete unassisted repetition will be recorded as the 1-RM.

DEVICE

Blood flow restriction exercise

Perform lower-extremity exercises (leg press, leg extension, leg curl, and calf extension) at an intensity of 30% of 1-RM with external compression applied to the proximal thigh of each leg.

BEHAVIORAL

Borg CR10 scale

Following each exercise session, participants will provide a rating of perceived exertion (RPE) for the session according to the Borg CR10 scale.

Sponsors & Collaborators

• University of Florida Clinical and Translational Science Institute (CTSI)

  collaborator UNKNOWN

• University of Florida

  lead OTHER

Principal Investigators

• Rene Przkora, MD · University of Florida

Study Design

Allocation

RANDOMIZED

Purpose

HEALTH_SERVICES_RESEARCH

Masking

SINGLE

Model

PARALLEL

Eligibility

Min Age

55 Years

Max Age

80 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2016-12-12

Primary Completion

2018-08-01

Completion

2018-08-01

Countries

• United States

Study Locations