DOuble SEquential External Defibrillation for Refractory VF

Summary

Despite significant advances in resuscitation efforts, there are some patients who remain in refractory ventricular fibrillation (VF) during out-of-hospital cardiac arrest. Double sequential external defibrillation (DSED) and vector change defibrillation have been proposed as viable options for patients in refractory VF. This cluster randomized trial will compare (1) continued resuscitation using standard defibrillation; (2) resuscitation involving DSED; or (3) resuscitation involving vector change defibrillation, in patients presenting with refractory VF during out-of-hospital cardiac arrest. The results of this study will provide high level evidence of the impact of both DSED and vector change defibrillation on ROSC and patient survival after OHCA.

Conditions

• Out-Of-Hospital Cardiac Arrest
• Ventricular Fibrillation

Interventions

PROCEDURE

Double Sequential Defibrillation

Defibrillation using pad placement in anterior-posterior position

PROCEDURE

Vector Change Defibrillation

Defibrillation using two defibrillators, one with pad placement in anterior-posterior position and the other with pad placement in anterior-anterior position delivering two rapid sequential shocks.

Sponsors & Collaborators

• Peel Regional Paramedic Services

  collaborator UNKNOWN

• Toronto Paramedic Services

  collaborator UNKNOWN

• Halton Region Paramedic Services

  collaborator OTHER

• County of Simcoe Paramedic Services

  collaborator UNKNOWN

• London Health Sciences Centre

  collaborator OTHER

• Middlesex-London EMS

  collaborator UNKNOWN

• Ottawa Paramedic Service

  collaborator UNKNOWN

• Sunnybrook Health Sciences Centre

  lead OTHER

Principal Investigators

• Sheldon Cheskes, MD · Sunnybrook Centre for Prehospital Medicine

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Model

CROSSOVER

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2019-09-10

Primary Completion

2022-08-01

Completion

2022-08-01

Countries

• Canada

Study Locations