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Postoperative Renal Failure in Cardiac Surgery PMSF-PVC Gradient Study

NCT04062786 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 130

Last updated 2019-08-20

No results posted yet for this study

Summary

Acute renal failure is a frequent and severe postoperative complication of cardiac surgery performed under extracorporeal circulation.

It is an independent risk factor for mortality and significantly increases the length of hospital stay.

The origin of renal insufficiency after extracorporeal circulation is multifactorial (long duration of extracorporeal circulation, hemodynamic instability per and post-extracorporeal circulation, prolonged hypotension, transfusion ...).

Nevertheless, an entirely different pathophysiological mechanism, though not recent, is less often mentioned but shows renewed interest. This is the concept of renal venous congestion which may be responsible for impaired renal function in the absence of cardiac dysfunction. Based on Guyton's circulatory model, the investigators approach this systemic venous hypertension through the measurement of the Pmsf-PVC gradient.

Conditions

  • Scheduled Heart Surgery
  • Valve Replacement
  • Coronary Artery Bypass

Interventions

OTHER

Pmsf-PVC gradient measurement

implementation of standard standard hemodynamic monitorin

Sponsors & Collaborators

  • University Hospital, Strasbourg, France

    lead OTHER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2019-02-21
Primary Completion
2019-02-21
Completion
2020-02-29

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04062786 on ClinicalTrials.gov