MedTrace Logo

Intravenous Lignocaine Infusion in Laparoscopic Donor Nephrectomy

NCT04052867 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 40

Last updated 2020-04-30

No results posted yet for this study

Summary

Background:

Administration of morphine as boluses or via a patient controlled analgesic device (PCA) has been the standard practice for donors after nephrectomy.

However, administration of morphine is far from being ideal analgesic as it does not provide optimal dynamic pain relief after major surgery, consistently demonstrate little effect on surgical stress response and organ dysfunction with high incidences of postoperative nausea/vomiting, respiratory depression and sedation. Several studies demonstrated perioperative intravenous lignocaine infusion can improve post-operative pain scores and morphine consumption in abdominal surgery.

The aim of this study is to identify the effectiveness of intra-operative lignocaine infusion in lowering postoperative pain and reduce postoperative morphine consumption in patients who undergo laparoscopic donor nephrectomy.

Conditions

  • Postoperative Pain
  • Renal Transplantation
  • Morphine Adverse Reaction

Interventions

DRUG

Lignocaine

Slow bolus of lignocaine is given over 15 min before the start of surgery, followed by infusion of lignocaine

DRUG

Normal saline

An equivalent volume of normal saline is given

Sponsors & Collaborators

  • University of Malaya

    lead OTHER

Principal Investigators

  • Pui San Loh, MBBS, MMed · University Malaya, Malaysia

Study Design

Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2019-09-17
Primary Completion
2021-07-15
Completion
2021-07-31

Countries

  • Malaysia

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04052867 on ClinicalTrials.gov