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TCDαβ/CD45RA Haploidentical Transplantation in Children With Leukemia

NCT04033627 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 30

Last updated 2022-09-29

No results posted yet for this study

Summary

This is a multi-center clinical study in China using CliniMACS TCRα/β+ and CD45RA+ T cell depleted stem cell grafts from haploidentical donors for hematopoietic stem cell transplantation in children.

Conditions

  • Relapsed Pediatric ALL
  • Acute Graft-Versus-Host Disease (Gvhd) Grade IV (Diagnosis)
  • Relapsed Pediatric AML

Interventions

PROCEDURE

In Vitro T cells depletion using CliniMCAS system

Use the CliniMACS TCRα/β and CD45 Systems to deplete TCRα/β+ and CD45RA+ cells from the mobilized peripheral blood stem cells of a haploidentical donor in patients with leukemia.

Sponsors & Collaborators

  • Nanfang Hospital, Southern Medical University

    collaborator OTHER

  • Children's Hospital of Soochow University

    collaborator OTHER

  • Chinese University of Hong Kong

    collaborator OTHER

  • Miltenyi Biomedicine GmbH

    collaborator INDUSTRY

  • Shanghai Children's Medical Center

    lead OTHER

Principal Investigators

  • Jing Chen · Shanghai Children's Medical Center

Study Design

Allocation
NA
Purpose
TREATMENT
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
2 Months
Max Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-11-10
Primary Completion
2022-07-18
Completion
2024-05-08

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04033627 on ClinicalTrials.gov