Safety Study of CD3/CD19 Depleted Haploidentical Stem Cells
NCT01919866 · Status: UNKNOWN · Phase: PHASE1/PHASE2 · Type: INTERVENTIONAL · Enrollment: 120
Last updated 2014-10-08
Summary
Feasibility and toxicity of haploidentical transplantation of CD3/CD19 depleted stem cells in combination with a toxicity reduced conditioning regimen or with standard conditioning regimens according to underlying disease.
Conditions
- Acute Leukemias
- Aplastic Anemia
- Childhood Solid Tumor
Interventions
- OTHER
-
Transplantation of CD3/CD19 depleted stem cells
Sponsors & Collaborators
-
University Children's Hospital Tuebingen
lead OTHER
Principal Investigators
-
Peter Lang, MD · University Children's Hospital Tuebingen
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 1 Year
- Max Age
- 25 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2004-03-31
- Primary Completion
- 2014-12-31
- Completion
- 2015-12-31
Countries
- Austria
- Germany
Study Locations
More Related Trials
-
CD45RA-depleted CD19-CAR T Cell Consolidation After TCRαβ+/CD19 B Cell-depleted Haploidentical Hematopoietic Cell Transplantation for Relapsed/Refractory CD19+ ALL and Lymphoma
NCT07257419 ·Status: RECRUITING ·Phase: PHASE1
-
Haploidentical Transplantation With CD3/CD19 Depleted Grafts in Patients With Hematologic Malignancies
NCT00202917 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Safety and Preliminary Efficacy of Donor-derived Anti-leukemia Cytotoxic T Lymphocytes for the Prevention of Leukemia Relapse in Children Given Haploidentical Hematopoietic Stem Cell Transplantation
NCT06865352 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
HLA-haploidentical Hematopoietic Stem Cell Transplantation for Children and Adolescents With Acute Leukemia, Myelodysplastic Syndrome and Solid Tumors
NCT01509300 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
Haploidentical Stem Cell Transplantation for Children With Therapy Resistant Leukemia
NCT01025778 ·Status: COMPLETED ·Phase: PHASE2
-
Haplo-identical SCT for High Risk (HR) Hematologic Malignancies w/Post-Transplant In-Vivo T-cell Depletion
NCT02053545 ·Status: WITHDRAWN ·Phase: PHASE1/PHASE2
-
Phase 1/2: CD45RA Depleted Stem Cell Addback to Prevent Viral or Fungal Infections Post TCRab/CD19 Depleted HSCT
NCT06839456 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
T Cell Depletion for Recipients of HLA Haploidentical Related Donor Stem Cell Grafts
NCT00368355 ·Status: COMPLETED ·Phase: PHASE2
-
Haploidentical Stem Cell Transplantation With CD3/CD19 Depletion and Reduced Intensity Conditioning in Patients With Acute Leukemia
NCT00961142 ·Status: TERMINATED ·Phase: PHASE2
-
Haploidentical Stem Cell Transplant for Treatment Refractory Hematological Malignancies
NCT00145613 ·Status: COMPLETED ·Phase: PHASE2
-
Haploidentical Allogeneic Hematopoietic Stem Cell Transplantation in Children and Adolescents
NCT02014506 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
Stem Cell Transplantation From HLA Partially-Matched Related Donors for Patients With Hematologic Malignancies
NCT02566395 ·Status: COMPLETED ·Phase: PHASE3
-
Haploidentical Hematopoietic Cell Transplantation for Children With Hematologic Malignancies and Myelodysplasia
NCT03431090 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1/PHASE2
-
Myeloablative Haploidentical BMT With Post-transplant Cyclophosphamide for Pediatric Patients With Hematologic Malignancies
NCT02120157 ·Status: COMPLETED ·Phase: PHASE2
-
Allogeneic Hematopoietic Stem Cell Transplantation for High-Risk Hematologic Malignancies Using One Haploidentical Donor
NCT01982682 ·Status: COMPLETED ·Phase: PHASE2
-
TCRαβ+/CD19+ Depleted Allogeneic Hematopoietic Stem Cell Transplantation for Malignant and Non-malignant Disorders
NCT04088760 ·Status: TERMINATED ·Phase: PHASE2
-
Donor Stem Cell Transplant After Chemotherapy for the Treatment of Recurrent or Refractory High-Risk Solid Tumors in Pediatric and Adolescent-Young Adults
NCT04530487 ·Status: TERMINATED ·Phase: PHASE2
-
Infusion of Allogeneic CD19-Specific T Cells From Peripheral Blood
NCT01497184 ·Status: COMPLETED ·Phase: PHASE1
-
Administration of Anti-CD19-chimeric-antigen-receptor-transduced T Cells From the Original Transplant Donor to Patients With Recurrent or Persistent B-cell Malignancies After Allogeneic Stem Cell Transplantation
NCT01087294 ·Status: COMPLETED ·Phase: PHASE1
-
Secondary Haplo HSCT for Relapse After Initial Allogeneic HSCT
NCT01997918 ·Status: COMPLETED
-
Haploidentical Hematopoietic Cell Transplantation Using TCR Alpha/Beta and CD19 Depletion
NCT05236764 ·Status: ACTIVE_NOT_RECRUITING ·Phase: NA
-
Myeloablative Hematopoietic Progenitor Cell Transplantation (HPCT) for Pediatric Malignancies
NCT00619879 ·Status: COMPLETED
-
Alpha/Beta T-cell Depleted Blood-forming Stem Cell Transplant From Related or Unrelated Donors for Blood Diseases in Children and Young Adults
NCT04806347 ·Status: NOT_YET_RECRUITING ·Phase: PHASE1
-
Haploidentical Allogeneic Hematopoietic Stem Cell Transplantation (HaploHCT) Following Reduced Intensity Conditioning (RIC) for Selected High Risk Non-Malignant Diseases
NCT03367546 ·Status: TERMINATED ·Phase: PHASE2
-
Combined T Cell Depleted Haploidentical Peripheral Blood Stem Cell and Unrelated Umbilical Cord Blood Transplantation in Patients With Hematologic Malignancies Using a Total Lymphoid Irradiation Based Preparative Regimen
NCT02199041 ·Status: TERMINATED ·Phase: PHASE2