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Acute Cognitive Changes During Atrial Fibrillation Episodes (AFCOG)

NCT04033510 · Status: ACTIVE_NOT_RECRUITING · Type: OBSERVATIONAL · Enrollment: 600

Last updated 2025-10-14

No results posted yet for this study

Summary

Objectives:

* First, to determine if patients with a history of AF have acute measurable changes in cognitive functioning while in an episode of AF.
* Second, to collect basic insight into what specific physiologic (blood pressure, pulse oximetry, heart rate, temperature) and pharmacologic (antiarrhythmic medications, rate control medications, anticoagulants, antiplatelet medications, etc.) factors minimize the neurological impact on patients while they are in AF.

It is hypothesized that when using a tablet-based cognitive testing software - Cambridge Cognition (specifically to assess executive function, learning and working memory: Rapid Visual Information Processing test, Spatial Working Memory/Spatial Span Task tests, One touch Stockings of Cambridge test, Cambridge Gambling Task, Multitasking Test/Intra-Extra Dimensional Set shift tests) - a significant difference will be noted between how the patients perform while in atrial fibrillation compared to the patients' performance while in normal sinus rhythm.

Conditions

Interventions

OTHER

Standard of Care Interventions to convert patient from atrial fibrillation to normal rhythm

Direct current cardioversion, PVAI-atrial fibrillation ablation, Minimally Invasive Surgical Maze procedure, Medications

Sponsors & Collaborators

  • Colorado Cardiac Alliance

    collaborator UNKNOWN

  • David Brunk, PA-C, MMS

    lead OTHER

Principal Investigators

  • David R Brunk, PA-C, MMS · Common Spirit

Eligibility

Min Age
35 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2019-08-14
Primary Completion
2024-11-25
Completion
2027-01-30

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04033510 on ClinicalTrials.gov