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Stress and Brain Response Using MEG in PWS

NCT04032639 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 48

Last updated 2022-09-13

No results posted yet for this study

Summary

Individuals with Prader-Willi Syndrome (PWS) have increased hunger and food seeking behaviour, as well as learning (cognitive) challenges. In addition, some patients with PW been shown to have low cortisol production, particularly in stressful situations. However, research examining how hormonal, cognitive, and psychological factors are interrelated PWS is limited. To address this gap in knowledge, the goal of this project is to understand how changes in brain regions involved in controlling food intake and cognitive processes are related to changes in hormones regulating appetite, the stress hormone cortisol, and performance on neuropsychological tests.

Conditions

Sponsors & Collaborators

  • Holland Bloorview Kids Rehabilitation Hospital

    collaborator OTHER

  • University of Western Ontario, Canada

    collaborator OTHER

  • The Hospital for Sick Children

    lead OTHER

Principal Investigators

  • Jill Hamilton, MD · The Hospital for Sick Children

Eligibility

Min Age
7 Years
Max Age
16 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2019-05-30
Primary Completion
2023-05-31
Completion
2024-05-31

Countries

  • Canada

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04032639 on ClinicalTrials.gov