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Circulating miRNAs and Bone Microstructure in Adults With Hypophosphatasia

NCT04018287 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 60

Last updated 2023-01-26

No results posted yet for this study

Summary

The aim of the study is to accomplish a complete bone status of patients with HPP using new approaches to assess bone quality.

Conditions

  • Hypophosphatasia
  • Bone Diseases, Metabolic
  • Bone

Interventions

OTHER

HR-pQCT scans, BMD measurements, bone specific circulating microRNAs (miRNAs)

HR-pQCT scans (XtremeCT, SCANCO Medical, Brütisellen, Switzerland) will be performed in all patients with HPP and all CTRL at the ultradistal radius and the distal tibia, using the manufacturer's standard protocol. Volumetric bone Mineral density (vBMD) will be carried out. The peripheral trabecular density adjacent to the cortex and the central medullary trabecular density will be automatically evaluated. Bone microstructure including trabecular bone volume fraction, trabecular number, trabecular thickness inhomogeneity of the network, cortical thickness and cortical porosity will be analyzed. Measurements will be carried out by two well-trained physicians and performed with the latest available software (software version 6.0). Daily crosscalibrations with standardized control phantoms (Moehrendorf, Germany) will be conducted for validation.

Sponsors & Collaborators

  • Medical University of Vienna

    lead OTHER

Principal Investigators

  • Roland Kocijan · Vinforce Study Group

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2017-08-01
Primary Completion
2023-03-01
Completion
2023-06-01

Countries

  • Austria

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04018287 on ClinicalTrials.gov