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Effect of Magnesium on Dose of Rocuronium for Deep Neuromuscular Blockade

NCT04013243 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 68

Last updated 2020-12-24

No results posted yet for this study

Summary

It is well known that magnesium enhances the effect of neuromuscular blocking agents such as rocuronium. However, it is not known how much magnesium can reduce neuromuscular blocking agents in maintaining deep neuromuscular blockade. Through this study, the investigators will quantitatively analyze the rocuronium saving effect of magnesium.

Conditions

  • Magnesium Sulfate Causing Adverse Effects in Therapeutic Use
  • Neuromuscular Blockade

Interventions

DRUG

Magnesium Sulfate

magnesium sulphate 50mg/kg in normal saline 50ml infusion for 10minutes for loading dose followed by 15mg/kg/hr for continuous infusion

DRUG

Placebo

Normal Saline 50ml infusion for loading dose followed by continuous infusion for same dose of magnesium.

Sponsors & Collaborators

  • Seoul National University Bundang Hospital

    lead OTHER

Principal Investigators

  • Ah-young Oh, professor · Seoul National University Bundang Hospital

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
20 Years
Max Age
80 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2019-04-26
Primary Completion
2019-07-30
Completion
2019-07-30

Countries

  • South Korea

Study Locations

More Related Trials

Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04013243 on ClinicalTrials.gov