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Adding Magnesium Sulfate to Bupivacaine for Ilioinguinal and Iliohypogastric Nerve Block

NCT05158647 · Status: COMPLETED · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 90

Last updated 2021-12-15

No results posted yet for this study

Summary

Regional block of ilioinguinal and iliohypogastric (IIIH) nerves has been applied to provide postoperative analgesia after inguinal hernia repair. Magnesium sulfate (MgSo4) blocks N-methyl-d-aspartate receptors, and that is why, it was used as an adjuvant to the local anesthetic (LA) in different anesthetic approaches. Although the prolongation in postoperative duration resulting from the addition of MgSO4 to LA was significant in some literature studies, it was insignificant in others. This study was designed to investigate the adjunctive effect of MgSo4 when added to bupivacaine for IIIH blockade on the postoperative analgesic duration as a primary outcome and on the verbal rating scale (VRS) scores, analgesic consumption, and hemodynamics as secondary outcomes.

Conditions

  • Magnesium Sulfate Causing Adverse Effects in Therapeutic Use

Interventions

OTHER

normal saline

10-ml 0.5% isobaric bupivacaine and 1ml normal saline were prepared for IIIH blockade

DRUG

MgSo4

10 ml 0.5% isobaric bupivacaine and 1ml of MgSo4 10% (100 mg) were used

Sponsors & Collaborators

  • Abdelrady S Ibrahim, MD

    lead OTHER

Principal Investigators

  • Mahmoud S Elmansy · Faculty of Medicine Mansoura University

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Model
PARALLEL

Eligibility

Sex
MALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-08-12
Primary Completion
2020-02-07
Completion
2020-04-21

Countries

  • Egypt

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05158647 on ClinicalTrials.gov